- Vital Voice begins publishing.
- JJs Clubhouse bar opens.
- St. Louis Black Lesbian and Gay Pride Committee is formed.
- St. Marcus Theatre closes.
- Hot House Theatre's production of Martin Sherman's Bent causes controversy.
- HIV/AIDS Ministry of the "Rock" Catholic Church opens via merger of two groups.
- Being edited/researched.
- Blacks Assisting Blacks Against AIDS (BABBA) becomes embrolled in scandle after hiring a porn star to appear at an event. BABBA would soon disband.
- City of St. Louis Health Department loses $3.2 million in AIDS related funding due to missing deadlines.
- 50 demonstrators from Soul Force are arrested in St. Louis after protesting the Southern Baptist National Convention in St. Louis.
- St. Louis Post-Dispatch begins publishing same sex wedding announcements.
- Bad Dog Saloon opens.
- Gateway Squares is founded.
- Jeanette Mott Oxford elected to the Missouri House.
- Drag Kings on Tour appear in St. Louis.
- Missouri voters approve ban on same sex marriage.
- Gateway Gay Rodeo Association forms.
- UMSL Safe Zone established.
- Fleishman Hillard PR forms lesbian and gay-focused communications unit.
- Chrissy Gephardt comes out.
- St. Louis hosts the 17th Annual Creating Change Conference of the National Gay and Lesbian Task Force.
- Forest Park Southeast rebranded as the Grove, now home of largest cluster of LGBT bars/clubs in St. Louis.
- Gateway Stonewall Democrats is formed.
- Police shut down the play "Making Porn" at the Spot for onstage nudity.
- Aquinas Seminary is visited by Vatican officials investigating "homosexuality."
- The Focus on the Family's International Love Won Out Conference is held in St. Louis. Pro gay protestors picket and deface conference billboards.
- National Gay Scientists Convention is held in St. Louis.
- Tennessee Williams' CWE apartment is renovated and put on market as a condo for $222,000.
- Lawyers for Equality is formed.
- Author Gregory Kompes lists St. Louis as one of the top 50 fabulous gay friendly places to live.
- Doorways' Partidge Place Apartments burns down during construction, arson suspected.
- Openly gay college athlete Adam Goslin graduates from Washington University.
- Prime Timers St. Louis and the St. Louis LGBT History Project are formed.
- PHD Gallery opens.
- National Baptist Convention USA is held in St. Louis. The convention for the first time featured a health forum on HIV/AIDS.
- B'Nani Amoona votes to allow same sex committment ceremonies at its synagogue.
- Public Defender Eric Afflholter is sentenced to one year probation for marriage fraud (had someone marry his partner to keep him in the country).
- Missouri Court of Appeals Judge Lawrence Mooney (openly gay) declines invitation from Archdiocese of St. Louis to attend their Law Day Mass because of what he called "abuse of gays and lesbians" by the church.
- The Gateway Sisters of Perpetual Indulgence is formed.
- A crowd of 1,400 gather at the Old Courthouse to protest the California Prop 8 ruling.
- Just John and Erney's 32 bars open.
- AIDS Foundaiton of St. Louis closes.
- QFest begins.
- Mike Colona elected to Missouri House of Representatives.
- Show Me No Hate organizes first in a multi-year series of "Marriage Equality" buses to Iowa, where gay marriage is legal.
- Rehab, Bad Dog Bar and Grill and Novak's bars open.
- MCC moves in to new building.
- St. Louisan Teresa Butz murdered in Seattle.
- "Seperate Church and Hate" rally held at Cathedral Basilica to protest church funds being used in Maine for an anti gay marriage campaign.
- Missouri state trooper Dennis Engelhard is killed, prompting debate on benefits for same sex partners.
- A man is beaten outside of the Complex bar, peace vigil is held.
- Shane Cohn elected St. Louis' 25th ward Alderman.
- Miss Gay America Pageant held in St. Louis.
- St. Louis hosts the NO8H photograpy project.
- Representatives from Growing American Youth and PROMO attend White House LGBT reception.
- That Uppity Theatre Company presents "State of Marriage" play.
- St. Louis LGBT History Project conducts CWE tour and hosts first treasure drive.
- St. Louis Board of Aldermen pass transgender protection bill.
- The LGBT Center of St. Louis moves to new location at 4337 Manchester Ave.
- Loading Zone bar closes after fire.
- Complex bar closes.
- Meyer's Grove bar opens.
- The St. Louis LGBT History Project commemorates Tennessee Williams 100th birthday.
- Uniiversity City approves same sex registry.
- Dr. Mark Pope, professor and chair of the Division of Counseling and Family Therapy at the University of Missouri–St. Louis, was named the 27th president of the American Psychological Association’s Division 44, the Society for the Psychological Study of Lesbian, Gay, Bisexual and Transgender Issues.
- Hamburger Mary's opens in St. Louis.
- Tim Craddick (Grandma) long time owner of area bars (Rainbow's End, Politician Lounge) passes away.
- St. Louis County, Ferguson, Clayton, Richmond Heights, Maplewood, and Kirkwood pass anti-discrimination ordinances.
- Teacher Al Fisher is fired after his employer St. Ann Catholic School learns he plans to marry his partner.
- St. Louis Pride, Inc., moves its June event to downtown St. Louis/Solider's Memorial.
- St. Louis LGBT History Project named the Community Organization Icon for 2013 by Vital Voice.
- Honey bar opens.
- Novak's bar closes.
- CJ's on the Hill Restaurant opens. (gay owned)
- St. Louis County, Maryland Heights, Webster Groves and Kirkwood, MO pass anti-discrimination ordinances.
- Premium Lounge begins to market itself as a gay bar.
- Sasha Nicole (Patrick McGuire) Miss Gay Missouri 2005 passes away.
- Missouri U.S. Senator Claire McCaskill endoreses gay marriage.
- Marriage equality rally held at City Hall.
- VA St. Louis Health Care System began the training of employees, physicians, staff, and allied healthcare professionals about the unique health care needs of LGBT veterans.
- Dr. Lynne M. Cooper, founder and former President of Doorways, passes away.
- The St. Louis Convention and Visitors Commission launches national ad campaign touting St. Louis as an LGBT destination.
- St. Louis selected to host the 2016 North American OutGames.
- Illinois legalizes same sex marriages.
- St. Louis Veteran's Day Parade features LGBT veterans.
- St. Louis LGBT History Project announces archival partnership with the Missouri History Museum.
- St. Louis celebrates its 250th birthday. Two LGBT artifacts are included in the Missouri History Museum's accompanying exhibit. A LGBT themed STL250 birthday cake sculpture is displayed in front of the LGBT Center.
- Project and PHD Gallery host St. Louis' first large scale/dedicated exhibit of local LGBT artifacts.
- Magnolia's Bar closes.
- WeHo Bar opens. (closes two months later)
- Siam Restaurant/Bar opens.
- CJ's on the Hill Restaurant is sold.
- LGBT Center of St. Louis announces it will move. Open a virtrual office until a new location is secured.
- St. Louis, Kansas City, and Ozarks LGBT History Projects co-present for the first time at Midwest Archives Conference in Kansas City.
- Out gay Mizzou football player Michael Sam drafted by the St. Louis Rams, then released. Picked up by Dallas Cowboys practice squad, and released.
- #Boom Magazine launches.
- Four same sex couples married in ceremony in St. Louis Mayor's Office. File lawsuit to have marriages recognized by state.
- University of Missouri adds gender identity, expression to nondiscrimination policy.
- Clementine's Bar closes.
- Hamburger Mary's closes.
- Erney's Bar owner Mark Erney agrees to a Alford plea, pleading guilty but maintaining his innocence on the charges of felony theft for diverting money from his partners in Hamburger Mary's.
- Missouri court ruling recognizes same-sex marriages legally performed in other states.
- St. Louis City’s Circuit Court Judge Rex Burlison rules Missouri’s marriage ban unconstitutional. Same sex marriages begin to take place across the state.
- Korner's Bar closes. Reopens as Bar: PM
- Bad Dog Bar & Grill closes.
- Andrew Caldwell's claim at a pentecostal COGIC (Church of God in Christ) religious conference in St. Louis, that he is gay no more becomes a viral Internet sensation.
- The St. Louis LGBT History Project announces archival partnership with the Missouri History Musuem.
- Bomber's Hideaway bar opens, closes.
- R Bar opens.
- Lilly's Music and Social House bar opens.
- Meyer's Grove bar closes.
- Monocole bar opens.
- Absolutili Goosed bar closes.
- Brickyard Tavern bar opens.
- The LGBT Center of St. Louis closes.
- St. Louis native Douglas Hallward-Driemeier, a partner at Ropes & Gray LLP in Washington, argues that states should recognize marriages performed in other states duirng the Supreme Court's hearing on same sex marriage.
- A former Lindenwood University wrestler was found guilty of exposing one of his sex partners to HIV and attempting to expose four others to the virus that causes AIDS.
- St. Charles hosts first Pride event featuring a full day of activities on May 30.
- First transgender memorial garden in the U.S is dedicated in St. Louis.
- The St. Louis LGBT Project announces partnership with Washington University in St. Louis for archival preservation and research. Project makes presentations and hosts history tours during the 2015 Organization of American Historians Conference in St. Louis.
- Siam bar closes.
- St. Louis' Transgender Memorial Garden featured on "I Am Cait" television show.
- Missouri Democrats led the longest filibuster (intentionally delaying the vote on a bill that would make it legal to discriminate against LGBT persons on the basis of religious conviction, by taking time to talk about it on the floor until the time for the vote has passed) in state history. Republicans ended the filibuster after 39 hours with an obscure procedure, “moving the previous question,” and the vote passed the bill.
- R Bar closes.
- Erney's 32 Bar closes.
- I Don't Know Bar closes.
- Attitudes Bar under managment by Dan Stoner closes.
- Lily's Music and Social House Bar closes.
- Rudis Men's Leather Societ forms, Bar PM serves as host bar.
- Pride St. Louis opens an LGBT Center at its offices.
- The St. Louis LGBT community hosts Orlando massacre vigil at the Transgender Memorial Garden.
- St. Louis City Hall flies transgender flag for first time.
- Attitudes Bar reopens.
- Soulard Stable Bar opens.
- St. Louis Blues Hockey hosts first pride day.
- St. Louis Cardinals hosts first pride day.
- Mapping LGBT St. Louis launched by Washington University.
- Four Strings Bar opens.
- Soulard Stable Bar closes.
- Alton Pride Festival formed.
- St. Louis Board of Alderman ban conversion therapy for minors.
- St. Louis LGBTIA+ Peer Support Help hotline launched.
- First Trans Pride March held (in reaction to police being in PrideFest parade).
- Attitudes bar closes.
- Pandemic cancels Pride festivals. PrideFest is held in a virtual format.
- Deon Johnson named Bishop of the Episcopal Diocese of St. Louis.
- Trinity Episcopal Church named to National Register of Historic Places (LGBT heritage).
- Hamburger Mary's (downtown location) closes.
- Missouri History Museum launches online Gateway to Pride exhibit.
- Steven Louis Brawley elected to State Historical Society of Missouri Board of Trustees (Project Founder).